FDA Approves Zubsolv, New Brand of Sublingual Buprenorphine

aaaaaazubsolv

Suboxone is getting competition from the generic preparations of buprenorphine/naloxone, and now another name-brand preparation has just been approved by the FDA.

It’s called Zubsolv, and the manufacturer, Orexo, says it takes less time to dissolve, is a smaller tablet, and tastes better. The company added a menthol taste. They also say their preparation has higher bioavailability, and the tablets come in two strengths: 5.7/1.4 buprenorphine to naloxone ratio, and 1.4/.36 ratio. The lower doses of buprenorphine per tablet are due to the higher bioavailability. Also, each tablet is contained in unit dose packaging, to reduce the risk of pediatric exposures.

Interestingly, the package insert says not to switch from one buprenorphine preparation to another, because other tablets have different amounts of buprenorphine than Zubsolv. That’s a problem for established patients. I’d like the manufacturer to give prescribers some information on how blood levels of their tablets compare to blood levels of other preparations of buprenorphine. I guess new patients could be started on Zubsolv.

On the company’s website, they claim that nine out of ten people prefer Zubsolv to Suboxone.

This medication should be available in pharmacies by September of this year.

I’m glad for every new buprenorphine product that’s released to the market, because I hope it brings the price down. Lower cost of medication means more opioid addicts could afford treatment.

I’m curious to see how this new preparation will be greeted by patients on buprenorphine.

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16 responses to this post.

  1. Posted by Lesly Martins on August 3, 2013 at 3:47 pm

    I am from South Africa and is really curious to know more about the product. How may I contact the company?

    Reply

  2. Posted by Joy Auren on August 3, 2013 at 9:15 pm

    Good stuff! Hope you have a good weekend! :)

    Reply

  3. Posted by kevin on August 4, 2013 at 2:54 am

    Good news

    Reply

  4. I just switched from film to these due to the savings. These are completely ineffective, I doubt they contain any bupe at all. I took 2 tablets (11.4mg compared to my normal 8mg strip) and still felt absolutely nothing. The longer the day went on, the worse my DTs got. I have no idea how these got approved by the FDA.
    Just a warning before you all get excited that you may save some money through competition.
    You get what you pay for, except in the case of Zubsolv, you get nothing.

    Reply

    • You are the first person I’ve heard from with personal experience with this new brand Zubsolv. Thanks for writing to let us know.

      Reply

    • Posted by estone on February 25, 2014 at 8:46 pm

      man Idk what your talking about ive been on them for 2 month and they are great because the strips don do shit for me and zub cost more than suboxone!

      Reply

  5. Posted by Heather huchison on October 12, 2013 at 5:23 pm

    Just switched yesterday from suboxone films to this new zubsolv and I love it. The suboxone made me nauseated every morning when I had to take it. I dreaded it; now I don’t mind taking it at all. Also I have noticed no changes at all. I will never go back. But it’s only been 48 hours so that could change but so far I am so thankful for this new med. instead of $800/month it’s $700/month. Big savings if we are thinking long term. Now this is only cheaper because of a $75 off coupon for cash payers. This coupon could expire and not be refurbished at any time, however for now this is helpful. Good luck to everyone. And I will say I have not looked back and I have been ten months without a single pill and I used so much every day. I was very dependent. I hope I never go back.

    Reply

  6. Posted by If you found this, now you know me. If you throw the first stone, I'll throw one back at ya. on November 22, 2013 at 7:24 pm

    The 3rd post back is bull $#!’. I too have taken Zubsolv and it freek’n works! I am a true addict. All started with a back injury and went from 3 x 7.5 vics a day in 2005 to $50 worth of China white (injected) a day in 2007. In 2007 sought treatment for my addiction and went on suboxon 8mg daily for 4 years. Relapsed in 2011 and sought a doc in another state for 2 x 30mg oxycodone a day with a 40mg opana here or there. Went back to rehab 6 months ago and tapered down to 4mg suboxon and the doc said “want to save money with a new pill?” of course! I’m taking half of my Zubsolv (equivalent to 4mg sub) in the morn and the other half afternoon, since this came out a couple months ago. High feeling all day, back feels great and so do I. I’m on nothing else. Hope you all seek help for this costly addiction. If I could go back to heroine or oxycodone I would in the blink of an eye. Zubsolv is saving me from an early grave. And others continue to live happy, I know… .

    Godspeed you black emperor’s

    Reply

  7. Posted by Mike on November 28, 2013 at 8:25 am

    Just took my first one, I have been on Suboxone 8 MG- SL Film for 7 months.
    I am very grateful to have a Doctor That Only charges me $50.00 per month for the visit.
    I have insurance that has also been very helpful they have paid for 60 per month with a $3.00Co-Pa for 7 months. This med seems to work well, I have only took one but it worked so far…my doc visit was $375.00 per month but we talked and he understands that I could not pay that. But his office is full how they get all this money !!!! Then the prescription cost of the medications I just could not.. SO I am doing fine now .

    Reply

  8. Posted by anonymous on December 4, 2013 at 2:14 am

    Recovering from a gripping two year Opana addiction. I was on buprenorphine for past year and a half. Recently started the Zubsolv 5.7-1.4. I am not a huge fan because my insurance does not cover it when the buprenorphine was covered. I do have physical detoxing symptoms much faster on the Zubsolv vs. Buprenorphine. I take my medication as prescribed but have been in a couple situations where I was unable to have my meds filled on time and/or missed a day due to being out of town (poor packing/ planning). The first time this happed I had gone 12 hrs with out my medication and started to detox. Detoxing like I would detox off the Opanas. Scared me to death. Cold sweats, gagging, vomitting, sneezing, shaking and the dreaded restless legs…GOOD TIMES. Haven’t had that feeling for years and never felt that way missing a normal dose of the buprenorphine. I understand that I must take my meds as prescribed but felt much safter knowing that I wasn’t going to immediatley detox if accidentally missed a dose. It’s a nice reminder that I’m still a drug addict and although the streets don’t have my soul the FDA/ Doctors/ Pharm sure have control of me and my cash. I believe these meds have saved people because they have saved me but unfortunatley I also beleive that greedy doctors keep patients strung out much longer than they should. Finding a good ethical doctor is part of the drug abuse / recovery problem.

    Reply

  9. Posted by Fun Times on December 12, 2013 at 1:46 am

    Took films for 7 months, generic tabs for 4 and this is my first month on Zubs. Pretty much the same as tabs while films work a little better. Only difference between tabs and Zubs is taste…

    Reply

  10. have been on zubsolv for 2 months now. started out taking 5,7 dose twice a day the first month. the second month I still felt wds so I went back to my doc and told her that I sometimes needed a third pill so she adjusted the zubsolv to 3 times a day only if I felt like ineeded it. this medication works great for me. I was taking 15 to 25 1000 mgs of loricet a day before taking zubsolv and withdrawls were horrible. I may as well have been a heroin addict. zubsolv has saved my life. even though its cheaper than suboxone it is still very expensive but at least im alive and doing well now.

    Reply

  11. Posted by Leza on January 28, 2014 at 4:35 pm

    Just started Zubsolv yesterday. Been on Suboxone for 4 years 8mg/2mg….went from 4 per day to 3/day. New script is for only 2 Zubsolv…so we’ll see how that’s going to work out for me. I have an auto-immune disease and an array of other health issues, so pain is a constant issue for me. Suboxone never took all the pain away, but it keep me at a steady level enough for me to be able to function in daily life again..b/c the narcotics weren’t doing anything for me anymore, but making me have to take more and more…well you folks know how that goes! In any case…it doesn’t feel quite the same as Sub in my opinion, but I’m going to give it a couple more days to really see how it goes. I will say I don’t like the fact I have to go back to tabs, I like the strips b/c I can cut them if I want to, whereas, the tabs crumble easy. I also am not crazy about the packaging, but understand the necessity of it. I have trouble with my hands and opening them are a nightmare. I also don’t like the menthol taste, probably because I’m just used to the other taste (which really isn’t great either, but if given a choice I’d rather have the old taste). So…it’s a wait and see …jury is still out for me.

    Reply

  12. Posted by Ian on March 1, 2014 at 10:48 pm

    Love your blog. You seem to be a Specialist that actually cares about the patients and not just in it for the dollar. I take bupe and it’s okay but it does not cover the deeply embedded paychological (almost physical their so intense) cravings. And it’s not an easy kick by any means itself. I have been on and off but mostly on it for the last 3 years, and have 4mg left. Tuesday will be my day that I start this extremely long W/D. Wish me luck, I’ll need it!

    Reply

  13. Posted by kevin on March 3, 2014 at 3:40 am

    Good luck to you. It’s a hard struggle. Be safe my friend

    Reply

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